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替吉奥单药或联合奥沙利铂治疗晚期结直肠癌有效性及安全性的meta分析
李伦瑾1, 樊新星1, 孙山1, 李俊2
1.成都大学附属医院/临床医学院药学部;2.成都大学附属医院/临床医学院普外科
摘要:
探讨替吉奥单药或联合奥沙利铂与卡培他滨单药或联合奥沙利铂治疗晚期结直肠癌的疗效和安全性。通过计算机检索,收集替吉奥单药或联合奥沙利铂与卡培他滨单药或联合奥沙利铂治疗晚期结直肠癌的随机对照试验(RCT),对纳入研究进行方法学质量评价,并采用RevMan 5.0软件进行meta分析。共纳入11个RCT,替吉奥组和卡培他滨组无进展存活率、总体生存率、中位无进展生存期、中位生存期、客观有效率、疾病控制率均无统计学差异(P>0.05);替吉奥组的手足综合征发生率低于卡培他滨组(P<0.05),两组在血液系统、周围神经系统、消化系统方面的不良反应发生率均无统计学差异(P>0.05)。替吉奥与卡培他滨治疗晚期结直肠癌有相似的疗效,但采用替吉奥手足综合征发生率低于卡培他滨。
关键词:  替吉奥  奥沙利铂  卡培他滨  晚期结直肠癌  手足综合征
DOI:10.11851/j.issn.1673-1557.2019.06.013
分类号:
基金项目:
Efficacy and safety of S-1 alone or combined with oxaliplatin in treatment of advanced colorectal cancer: a meta-analysis
Li Lunjin,Fan Xinxing,Sun Shan,Li Jun
Abstract:
To investigate the efficacy and safety of S-1 alone or combined with oxaliplatin and capecitabine alone or combined with oxaliplatin in the treatment of advanced colorectal cancer Randomized controlled trials (RCTs) of S-1 alone or combined with oxaliplatin and capecitabine alone or combined with oxaliplatin in the treatment of advanced colorectal cancer were collected by computer search Methodological quality of the included studies was evaluated and meta-analysis was performed using RevMan 5.0 software A total of 11 RCTs were included There were no significant differences in progression-free survival, overall survival, median progression-free survival, median survival, objective efficacy and disease control rates between the S-1 group and the capecitabine group(P>0.05) The incidence of hand-foot syndrome in the S-1 group was lower than that in the capecitabine group(P<0.05) There were no significant differences in the incidences of adverse reactions in blood system, peripheral nervous system and digestive system (P>0.05) S-1 and capecitabine have similar efficacy in the treatment of advanced colorectal cancer, but the incidence of hand-foot syndrome using S-1 is lower than that using capecitabine
Key words:  S-1  oxaliplatin  capecitabine  advanced colorectal cancer  hand-foot syndrome
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